Abstract 713
Background
Breast cancer is the most common cancer among women. Cyclophosphamide-based chemotherapy is an effective treatment procedure for breast cancer but some toxicities such as neutropenia are seen to emerge during chemotherapy. GSTP1 and ABCC4 are two significant enzymes that are involved in cyclophosphamide metabolism and transport respectively.
Methods
In this study, we investigated the impact of two common polymorphisms of GSTP1 (rs1695) and ABCC4 (rs9561778) genes on outbreak of grade 3/4 febrile neutropenia in Iranian breast cancer patients using ARMS-PCR and sequencing methods. Results analysis was done with SPSS Software.
Results
Based on statistical analysis, no meaningful association between the above-mentioned polymorphisms and outbreak of grade 3/4 febrile neutropenia was observed. But higher frequency of allele A of GSTP1 (rs9561778) and allele G of ABCC4 (rs1695) genes polymorphism in the control group indicate their protective role against outbreak of grade 3/4 febrile neutropenia. Although clinical findings demonstrated statistically meaningful association of cancer stage IIIC (p = 0.037) and existence of other diseases (p = 0.026) in addition to breast cancer with outbreak of grade 3/4 febrile neutropenia.
Conclusions
Based on our results, combination of molecular and clinical findings could be useful in prediction of high risk breast cancer patients for outbreak of grade 3/4 febrile neutropenia.
Clinical trial indentification
Legal entity responsible for the study
Medical Genetics Department of National Institute of Genetic Engineering and Biotechnology, Radiation Oncology Department of shohadaye 7Tir hospital of Iran University of Medical Sciences
Funding
Medical Genetics Department of National Institute of Genetic Engineering and Biotechnology, Radiation Oncology Department of shohadaye 7Tir hospital of Iran University of Medical Sciences
Disclosure
All authors have declared no conflicts of interest.
